
Why Calimate May Cause Constipation?
This article presents a case involving a patient who was taking calcium polystyrene sulfonate (generic name, hereafter referred to as Ca-type ion exchange resin), marketed in Japan under the brand name Kalimate, for the treatment of hyperkalemia.
The patient was in a nearly bedridden condition, and after starting oral administration of the drug, developed extremely hard stools and severe difficulty with defecation.
Constipation has been reported as a side effect of this medication, but in this case the symptoms were particularly severe. (This is an individual example, and the severity of symptoms varies among patients.)
Using this case as a starting point, I would like to review the mechanism of action of the drug and organize the possible factors that may influence stool consistency.